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WHEN ERICA BRITTON, 31, was diagnosed with melanoma at the age of 23, her family history of ovarian cancer prompted her physicians to test her for inherited mutations in the BRCA1 and BRCA2 genes. Inherited mutations in these genes, or germline mutations, are most commonly associated with increased risk for breast cancer and ovarian cancer; however, some research has also linked the mutations to an increased risk for certain skin cancers, including melanoma.  (Source

Significant progress has been made toward understanding the genes that contribute to inherited susceptibility for melanoma in some patients [3]. Uncommon, but high-risk, tfab-get-over-it-ugliest-devalleles contribute to the hereditary cancer phenotype that includes multiple cases of the associated cancer or cancers on one side of the family, multiple primary cancers in a given individual, and early age of onset for a given cancer. With further advances in both genomic technologies and the conceptual framework to isolate more prevalent, but lower risk, alleles, the spectrum of genetic lesions that contribute to melanoma risk can be expected to broaden. The genetic risk factors for melanoma are discussed here, along with potential implications for genetic screening. Other risk factors associated with the development of melanoma are discussed separately.(Source)